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Introduction
S-Adenosyl-L-Methionine Powder 29908-03-0, also know as SAMe, is a physiologically active molecule that exists in human tissues. It is synthesized by SAMe synthase catalyzing methionine and ATP. It acts as a methyl donor and a precursor of physiological sulfhydryl compounds to participate in chemical reactions in the body.
Main Function
1.Improve depression
-In the cerebrospinal fluid of depressed patients, the lower the concentration of 5-HIAA (a metabolite of 5-hydroxytryptophan), the more severe the depression. Supplementation of exogenous SAMe may promote the synthesis of 5-HIAA.
2.Antioxidant, reduce liver cell damage
-Significantly reduce the level of reactive oxygen species (ROS) in ethanol-treated liver cells.
-Promote the production of endogenous glutathione, improve detoxification and antioxidant function.
3.Detoxification, resist the damage of harmful substances to liver cells
-Promote the production of endogenous glutathione, improve detoxification and antioxidant function. Repair liver cells, improve membrane fluidity, increase the enzyme activity of Na+-K+-ATP, repair cytoskeleton, and improve liver cell function
-Protection of cell membrane: protect the lipid environment of cell membrane, maintain the enzymatic activity of Na+-K+-ATP of normal liver cell membrane and improve bile process and secretion.
-Protect the cytoskeleton: prevent the destruction of bile duct function caused by encircling toxin A (CyA); reduce the formation of micronucleus cells caused by cytoskeleton destruction drugs; protect the integrity of microtubules.
4.Promote liver cell regeneration
-Significantly increase the mitotic activity of liver cells in the early stage
5.Anti-liver fibrosis, delay the progression of liver disease
-It can inhibit the activation of hepatic stellate cells.
-It can inhibit the expression of TNF and promote the expression of IL-10, thereby inhibiting inflammation and combating liver fibrosis.
6.Increase insulin sensitivity and improve lipid metabolism
-Can increase mtDNA density and improve insulin sensitivity
Application
S-Adenosyl-L-Methionine Powder 29908-03-0 can be widely used in health products and pharmaceuticla products.
Specification
Items |
Specification |
Appearance |
White to off-white powder |
Identification |
Infrared |
HPLC |
|
Water(K.F) |
≤3.0% |
Sulphated Ash |
≤0.5% |
pH (5% Aqueous Solution) |
1.0-2.0 |
S, S-Isomer(HPLC) |
≥75.0% |
SAM-e ION(HPLC) |
49.5~54.7% |
P-Toluenesulfonic Acid |
21.0~24.0% |
Sulfate(SO4)(HPLC) |
23.5-26.5% |
S-Adenosy-L-methionine |
95.0~103% |
Related Substances(HPLC): |
|
-S-Adenosyl-L-Homocysteine |
≤1.0% |
-Adenine |
≤1.0% |
-Methylthioadenosine |
≤1.5% |
-Adenosine |
≤1.0% |
-Total Impurities |
≤3.5% |
|
Heavy Metals Lead Mercury Arsenic Cadmium |
≤10ppm ≤3ppm ≤0.1ppm ≤2ppm ≤1ppm |
Microbiology |
|
Total Aerobic Count |
≤1000cfu/g |
Yeast & Mold |
≤100cfu/g |
E. Coli |
Absent/10g |
S. Aureus |
Absent/10g |
Salmonella |
Absent/10g |
Conclusion |
Conform with USP37 standard. |
Flow Chart
http://www.konochem.com/
